Pharmacogenomics

Pharmacogenomics is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. By doing so, pharmacogenomics aims to develop rational means to optimise drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Such approaches promise the advent of "personalized medicine", in which drugs and drug combinations are optimised for each individual's unique genetic makeup.

Pharmacogenomics is the whole genome application of pharmacogenetics, which examines the single gene interactions with drugs.

Benefits of Remote Service Software

Remote service software helps to:

* Increase uptime, improve performance and extend the life of a device
* Control service costs by deploying patches and upgrades remotely, and ensure a first-time fix when an onsite visit is required
* Streamline administration of pay-per-use models, with automated usage monitoring
* Focus highly trained service teams on preventative maintenance, by diagnosing and repairing issues before they cause system failure
* Increase customer satisfaction and loyalty

Manufacturers are using aftermarket service a competitive differentiator. Remote service software provides a platform for manufacturers to offer and meet stringent service level agreements (SLAs) without increasing the size of their service team.

Locative media

Locative Media are media of communication bound to a location. They are digital media applied to real places and thus triggering real social interactions. While mobile technologies such as the Global Positioning System (GPS), laptop computers and mobile phones enable locative media, they are not the goal for the development of projects in this field. Rather:

"Locative media is many things: A new site for old discussions about the relationship of consciousness to place and other people. A framework within which to actively engage with, critique, and shape a rapid set of technological developments. A context within which to explore new and old models of communication, community and exchange. A name for the ambiguous shape of a rapidly deploying surveillance and control infrastructure." (Russell, 2004)

Inertial navigation systems in detail

INSs have angular and linear accelerometers (for changes in position); some include a gyroscopic element (for maintaining an absolute angular reference).

Angular accelerometers measure how the vehicle is rotating in space. Generally, there's at least one sensor for each of the three axes: pitch (nose up and down), yaw (nose left and right) and roll (clockwise or counter-clockwise from the cockpit).

Linear accelerometers measure how the vehicle is moving in space. Since it can move in three axes (up & down, left & right, forward & back), there is a linear accelerometer for each axis.

A computer continually calculates the vehicle's current position. First, for each of the six degrees of freedom (x,y,z and θ x, θ y and θ z), it integrates the sensed amount of acceleration over time to figure the current velocity. Then it integrates the velocity to figure the current position.

Inertial guidance is difficult without computers. The desire to use inertial guidance in the Minuteman missile and Project Apollo drove early attempts to miniaturize computers.

Inertial guidance systems are now usually combined with satellite navigation systems through a digital filtering system. The inertial system provides short term data, while the satellite system corrects accumulated errors of the inertial system.

An inertial guidance system that will operate near the surface of the earth must incorporate Schuler tuning so that its platform will continue pointing towards the center of the earth as a vehicle moves from place to place.